ABSTRACT
Background: Serum levels of total insulin-like growth factor I (IGF-I) reflect endogenous growth hormone (GH) secretion in healthy adults, which makes it a good diagnostic marker for screening of GH-related disorders. Studies also have supported a possible relation between IGF-I levels and the risk and prognostic for some malignancies, besides a relation between IGF-I levels and mortality. Objective: As the determination of the IGF-I normal values for local populations is strongly desired, the aim of this investigation was to determine reference values for IGF-I using an immunoradiometric assay (IRMA) in an adult Brazilian population of Rio de Janeiro city, since there is no other study using this methodology in Brazilian population, and that this method is widely used in Brazil and worldwide. Materials and Methods: The study included samples of blood taken from 484 healthy subjects (251 men and 233 women) aged 18-70. The subjects agreed with this study, approved by the Ethical Committee of the Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti, Rio de Janeiro, Brazil. The samples were analyzed using a Diagnostic System Laboratories kit. For data analysis, age- and sex-specific figures were fitted after transformation of IGF-I values. Results: In adulthood, a slow age-dependent decrease was found. There was no significant difference in IGF-I values between men and women. Conclusion: This study established age-specific IGF-I reference values, for a healthy Brazilian adult population, determined by a widely IGF-I, IRMA used currently in Brazil.
ABSTRACT
It is well known that reactions are commonplace occurrences during the course of leprosy disease. Stigmatization may even be attributable to reactions which are also responsible for the worsening of neural lesions. A cohort of 162 newly-diagnosed baciloscopically positive patients from the Leprosy Care Outpatient Clinic of the Oswaldo Cruz Foundation (FIOCRUZ) was selected for this study. While 46% of the multibacillary (MB) patients submitted to the 24 fixed-dose multidrug therapy (MDT) regimen suffered reactions during treatment, it was found that all MBs were susceptible and that constant attention and care were required at all times. Fourteen per cent were classified as BB, 52% as BL, and 33% as LL. None of the variables under study, such as, sex, age, clinical form, length of illness, length of dermatological lesions, baciloscopic index (BI), or degree of disability proved to be associate with reaction among the patients studied. Reversal Reaction (RR) occurred in 45%, and Erythema Nodosum Leprosum (ENL) occurred in 55%. Among BB patients who developed reactions (15 patients), 93% presented RR; while among the LL patients who developed reactions (34 patients), 91% presented ENL. Likewise, ENL was very frequent among those with disseminate lesions, while RR was most often observed in patients with segmentary lesions. RR was also most likely to occur during the initial months of treatment. It was demonstrated that the recurrence rate of ENL was significantly higher than that of RR. Neither grade of disability nor BI was shown to be associated with RR and ENL reaction. However, the RR rate was significantly higher among patients showing BI 3
Subject(s)
Male , Female , Humans , Child , Adult , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/diet therapy , Leprosy/diet therapy , Drug Therapy, CombinationABSTRACT
Reacoes sao ocorrencias comuns no curso da hanseniase e sao responsaveis pelo agravamento das lesoes neurais. Uma coorte de 162 pacientes recem-diagnosticados, baciloscopicamente positivos, em acompanhamento no Ambulatorio de Hanseniase da Fundacao Oswaldo Cruz (FIOCRUZ) foi selecionada para estudo. Observou-se que 46 por cento dos pacientes multibacilares submetidos a 24 doses fixas de poliquimioterapia (PQT) apresentaram reacoes durante o tratamento; todos multibacilares eram suscetiveis e cuidados e atencao constantes eram necessarios. Quatorze por cento foram classificados como BB, 52 por cento como BL e 33 por cento foram classificados como LL. Nenhuma das variaveis em estudo, tais como: sexo, idade, forma clinica, tempo de doenca, extensao das lesoes dermatologicas, indice baciloscopico (IB), ou grau de incapacidade associaram-se a reacao entre os pacientes estudados...
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Leprosy/complications , Leprostatic Agents/therapeutic use , Skin Manifestations , Biopsy , Chi-Square Distribution , Erythema Nodosum/etiology , Follow-Up Studies , Leprosy/drug therapy , Leprostatic Agents/adverse effects , RecurrenceABSTRACT
Através do Sistema de Vigilância Alimentar e Nutricional no município de Niterói, Rio de Janeiro foi realizado um estudo com 2248 crianças de 0-60 meses, residentes em tres distritos sanitários da cidade, durante sua campanha de vacinaçäo em 1992, objetivando o diagnóstico do estado nutricional a partir dos índices: peso/idade (P/I), peso/altura (P/A), altura/idade (A/I). Foi utilizado o padräo NCHS, classificaçoes Gomez e escore-z. A prevalência da desnutriçäo foi estudada a partir da proporçäo de crianças com índice antropométrico menor que -2,00 escore-z, considerando-se A/I para as formas crônicas e P/A para as formas agudas. Os resultados indicam que 20,1 por cento das crianças possuíam desnutriçäo (total da cidade, classificaçäo Gomez). A avaliaçäo do escore-z para A/I, evidenciou que 6,8 por cento das crianças na cidade possuíam desnutriçäo crônica. Os resultados indicam uma situaçäo séria de desnutriçäo crônica em Niterói, especialmente em seu distrito leste.